The Houston Rockets may have a tough one on their hands as they'll be without guard James Harden when they take on the Los Angeles Clippers Wednesday at 10:30 pm ET.

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Harden is among the league leaders with 26.1 points per game. He's been even better over the past four games, averaging 32.0 points on 54.1 percent shooting -- 12 for 27 from long range.

Harden had 27 in Tuesday's 116-107 victory at Golden State, but stepped on David Lee's left shoe going for a fast-break layup and his right ankle twisted violently. He returned, but his reaction after the win hardly sounded like someone who'd be ready to go in less than 24 hours.

If Harden is out, Houston may need another big effort from Chandler Parsons, who had 21 points, nine assists and eight rebounds Tuesday. The second-year forward is second on the team with 14.5 points per game, and will participate in the NBA's Rising Stars Challenge during All-Star weekend.

While the Rockets are off until next Wednesday after this meeting, that's not the case for the Clippers. They'll be the road team against the Los Angeles Lakers on Thursday night.

Meanwhile, Los Angeles has also taken three straight in the series at Staples Center, including a 95-91 victory behind Paul's 23 points and five steals in the most recent meeting there March 17.

Paul has averaged 24.8 points over his past four games against Houston, but Crawford did much of the damage with Paul out last month. He scored a game-high 30 points, including 12 straight to start the fourth quarter.

This time, Los Angeles may be without guard Chauncey Billups and forward Caron Butler, who are hampered by sore lower backs that kept them out of the win over the 76ers.