Tottenham will face an extremely tough Round of 32 tie against Olympique Lyonnais Thursday at 3:00 pm ET.

Watch and listen online to Tottenham vs. Olympique Lyon, click here.

Andre Villas-Boas is set to make some changes from the side that defeated Newcastle United 2-1 on Saturday with Benoit Assou-Ekotto and Jan Vertonghen poised to come into the starting lineup to freshen up the back line.

Further forward, Emmanuel Adebayor is likely to start his first match for the club since returning from the Africa Cup of Nations. Younes Kaboul (knee) and Jermain Defoe (ankle) both remain a couple of weeks away from returning. Sando (knee) will miss the rest of the season.

For the hosts, Remi Garde could also change the team which lost 3-1 at home to Lille. Yoann Gourcuff has struggled to make the starting XI for the club on a consistent basis but could be given a chance to add to his three appearances in the Europa League.

Up front Bafetimbi Gomis may also potentially come in to give increased attacking options alongside fellow strike partner Lisandro Lopez.

Probable Lineups:

Tottenham: Lloris, Walker, Dawson, Vertonghen, Assou-Ekotto, Lennon, Dembele, Parker, Bale, Dempsey, Adebayor

Lyon: Vercoutre, Reveillere, Dabo, Bisevac, Umtiti, Ghezzal, Gourcuff, Gonalons, Malbranque Lopez, Gomis