Real Madrid will have one eye on the Champions League game against Borussia Dortmund when they host Real Betis in their La Liga game.
The Spanish champions have already given up on retaining their Spanish League title, with Barcelona leading the table by 13 points with a mere seven games left.
However, Real will be keen to hold onto second spot from neighbors Atletico Madrid, who are only three points behind, even of the Champions League might be a bigger priority.
Mourinho will rest a lot of his key players against Betis, with Iker Casillas again set to warm the bench.
"Ronaldo is in the squad," Mourinho said. "Those who are not are missing through injury and suspension, as is the case of Xabi (Alonso). (Sami) Khedira and Sergio Ramos have not been named in the squad.
"Casillas will be on the bench tomorrow (Saturday). Diego (Lopez) will play, but he is fully fit to play. It should come as no surprise if Casillas plays one day because he is fully fit.
"It is ideal for me and for everyone that we have two fully fit goalkeepers like these and two good young keepers behind them."
Mourinho is not taking the result against Betis for granted, with their opponents currently seventh on 48 points, fighting for a place in Europe for next season.
"They are a very good team with good players, a good manager, a good attitude and they are set up to win games away from home," Mourinho said. "They defend well as a team, they attack at pace, they have great individual players going forward.
"They are a very good team. It is a difficult game and I'm glad; I want them to finish well, but I hope that we can get a good result."
Real Betis will be without Nacho, who suffered a toe injury in training, while Mario is also ruled out with a hamstring issue. Nosa Igiebor is also a slight doubt.
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Expected lineups: Real Madrid: Diego Lopez; Arbeloa, Albiol, Pepe, Marcelo; Essien, Modric; Callejon, Kaka, Ronaldo; Benzema.
Real Betis: Adrian; Chica, Paulau, Amaya, Martinez; Pabon, Canas, Benat, Campbell; Molina, Castro.
Prediction: 4-1 to Real Madrid