Matt Cain will attempt to end his longest losing drought of his career when he and the rest of the San Francisco Giants look to get a win on the road against the Arizona Diamondbacks at 9:40 p.m. ET.

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Via ESPN:

Cain and the defending World Series champs will try to snap a five-game losing streak on Monday night when they open a three-game series against Kennedy and the Arizona Diamondbacks at Chase Field.

After a 9-4 start, slumping San Francisco (13-12) dropped its eighth in 12 games with a 6-4 loss at San Diego on Sunday.

"We haven't been playing so well," manager Bruce Bochy said. "We've been making mistakes that have hurt us in this little streak we are in."

The Giants haven't lost six in a row since suffering seven straight defeats from June 26-July 2, 2010, and turn to Cain to get them back on track.

Cain (0-2, 6.59 ERA), though, is still searching for his first victory after pitching inconsistently over his first five starts. It's the longest he's gone winless to open a season since 2008, when he didn't get his first victory until his sixth start.

After allowing seven runs in six innings in a 7-2 loss at Milwaukee on April 18, Cain gave up three earned and five hits over six innings in a 6-4, 11-inning loss to Arizona on Tuesday.

"I thought he regrouped and threw the ball well," said Bochy, whose club dropped two of three to the Diamondbacks.

Cain has pitched well in this series, winning nine of 11 decisions with a 2.95 ERA over his last 14 starts.

The three-time All-Star, however, will have to do a better job keeping the ball in the park. He's allowed six home runs over his last three starts, including Paul Goldschmidt's two-run blast in the last meeting.