The US Open 2014 Tennis major is live on Wednesday night for the men's and women's singles round of 16 and quarterfinals into the semis and the match live stream schedule on ESPN and WatchESPN as Serena Williams, Novak Djokovic, Andy Murray and Flavia Pennetta are in action and the matchups will be on Arthur Ashe and has a chance to be very good as two of the best players in the world battle.

Murray and Djokovic is one of the top matches of the tournament and those two come in as past winners here. Murray is low due to injuries and that is why the two are meeting this early, while Roger Federer has the chance to keep things going with Nadal out. Gael Monfils and Federer are playing in the next round and they will be one of the better matchups in that round and they are facing off to see who will advance into the semifinals of the tournament.

Federer has been looking very good for this tournament and now Gael Monfils is into the next set and will be in the quarterfinals in Queens for the first time since 2010. Monfils has made it to one semis in a Grand Slam and that was back in 2008 at the French Open and now he has the chance to do it again. Federer has continued his strong play and he will be very tough to get past in this tournament.

Victoria Azarenka went down and now that is yet another upset at the tournament and she had a tough day and now Ekaterina Makarova is through to the semifinals. Williams is the top name left and she looks to be the favorites for the rest of the tournament and Azarenka now has had a tough year and it continues with this loss. Azarenka said she was not feeling good and that is one reason why she lost to Ekaterina Makarova, who now has napped a streak of losing the last four major quarterfinals matches.

Williams will have one less thing to worry about when it comes to doubles, as she lost along with her sister and now she can concentrate on singles. Williams is the only one defending her title here this season, as Rafael Nadal is out with a wrist injury and Williams has continued to play well and now she has advanced farther than she has at any grand slam this year. Williams is looking like the strongest woman and with so many upsets on that side, she should be through.

Check here for the US Open 2014 Tennis live coverage from ESPN for the session.