The New England Patriots and Buffalo Bills are playing on the NFL schedule for Week 6 and the matchup at Ralph Wilson Stadium is at 1 pm ET on FOX and comes as the Bills have new ownership and the AFC East matchup is big for both teams, as the division is wide open and Tom Brady comes in after a big win for NE against the Bengals last week.

Brady comes in with an ankle injury and many are thinking that this could be an upset game for the Bills and with all the emotion after the team sale, it could be big in western NY. The Patriots come in after a nice win against the Bengals and they are looking to win again after losing badly to the Chiefs two weeks ago.

Check here for the New England Patriots and Buffalo Bills live coverage.