New England Patriots tight end Aaron Hernandez left Sunday's 20-18 loss against the Arizona Cardinals with a right ankle injury and did not return.
Initial X-rays on the ankle did not reveal a broken bone, but Hernandez will have an MRI on his right ankle Monday, according to a league source.
After the game, Hernandez left the game with the assistance of crutches and Patriots coach Bill Belichick did not have an update on Hernandez's status immediately following the game.
Hernandez was tied up while blocking on a screen pass to receiver Julian Edelman early in the first quarter.
The Patriots struggled offensively without Hernandez and did not reach the end zone until Tom Brady found Rob Gronkowski for a 5-yard touchdown with just more than two minutes remaining in the game.
"You can't go into the game just counting on one guy, any guy," Belichick said. "Everybody has to be ready to adjust. It's not the first time a player has been injured in a game."
The injury caused the Patriots to drastically alter their offensive personnel. After using two or more tight ends on all 67 offensive plays in Week 1 against the Tennessee Titans, New England used a pair of tight ends on just 20 of 77 offensive plays Sunday.
Since the 2011 season, the Patriots used two tight ends or more on 80 percent of their offensive plays.
"He's part of the game plan the whole week, obviously," Gronkowski said. "He's a great player. You just gotta be prepared though -- any time, any situation for anything. We gotta be more prepared and be able to go out and do the offense."
Brady said he was uncertain whether Hernandez's absence slowed the Patriots' offense.
"We have an offense with him in the game and without him in the game," Brady said. "Guys go in and out, and you lose guys over the course of a game and you have to be able to adjust.
"I'm sure he's not going to be the only one we lose this year at some point, but we have to figure out a way to still move the ball effectively throughout the course of the game -- enough where we can score more than 18 points."