Demar Dotson (Tackle)(Tampa Bay Buccaneers): Dotson will be out for 6 weeks thanks to an MCL sprain. Dotsons absence will force the Buccaneers to look at Gosder Cherilus former Colts lineman.

Rueben Randle (Wide Receiver) (New York Giants): Randle suffering from knee tendinitis, only lasted 3 plays in the preseason opener. This is another blow to the Giant's receiving core who already are trying to ease Odell Beckham JR and Victor Cruz back into action.

D'Joun Smith (Defensive Back)(Indianapolis Colts): Suffered a concussion in the Colt's preseason game.

Jarius Wynn (Defensive Lineman) (Buffalo Bills): Wynn suffered a torn ACL in the first week of preseason officially ending his season.

Jeff Allen (Right Tackle) (Kansas City Chiefs): Allen suffered an MCL sprain in preseason action.

Knile Davis (Running Back) (Kansas City Chiefs): Davis suffered a minor knee sprain, but was seen practicing on Monday.

Phil Loadholt (Right Tackle)(Minnesota Vikings): Loadholt tore his Achilles tendon during the first week of preseason, ending his season, and leaving a gaping hole for his replacement.  

Trumaine McBride (Defensive Back)(New York Giants): Injured his hamstring in preseason action.

Antone Smith (Running back) (Atlanta Falcons) strained his hamstring after scoring a touchdown in the first week of preseason.