Sammy Watkins (Wide Receiver): Watkins is one of the most exciting rookies of 2014, injuries however hampered his rookie year. Watkins will be relying on the unproven quarterback, Tyrod Taylor. If Taylor can prove to be an effective quarterback for the Bills he might be able to get Watkins the fantasy points owners are expecting. Watkins will fail to meet expectations if Taylor does not prove to be a capable pocket quarterback. Watkins is also injury prone so it is almost a guarantee he will miss some time.

LeSean McCoy (Running Back): Shady is already injured with a mild hamstring injury that has kept him out of most of the preseason. This is a cause for concern however Shady will get a lot of carries this season. Rex Ryan will run him into the ground however this will only be effective if he can stay healthy.

Karlos Williams (Running Back):  Williams will strictly be a hand cuff to Shady however he can find his own value if McCoy cannot stay healthy.

Charles Clay (Tight End): Clay is not in an advantageous position since this Bills offense has been somewhat slow this preseason. Clay could have a big year if Tyrod Taylor can find some chemistry with the athletic tight end.