Oakland Raiders
Derek Carr (Quarterback): Carr broke out last week throwing for 3 touchdowns so this could be a sign that the Raiders offense is beginning to click after all they did beat the Ravens. Carr is facing a tough secondary that will have its hands full with Amari Cooper and Michael Crabtree. This could be a nice matchup for Carr but this Browns defense is a tough one, he is a mid-tier QB2.
Amari Cooper/Michael Crabtree (Wide Receiver): Cooper and Crabtree will likely have a tough day facing the Browns secondary. Cooper should see the top coverage this defense has to offer and it will most likely be Joe Haden. Haden can shut down receivers so the fantasy flex start would have to go to Crabtree considering he may be the only player to find a hole in this secondary.
Latavius Murray (Running Back): The Browns defensive line is stout however Murray is a playmaker. The Raiders offensive line is something to take into account but he should still find his way into the end zone at some point.
Cleveland Browns
Isaiah Crowell/Duke Johnson (Running Backs): The Browns passing game is a nightmare except for when Johnny Manziel goes deep down the field for Travis Benjamin, that play works every time. Crowell and Johnson actually broke out and had a decent day rushing the football and this could be the matchup where they put up a ton of points. The Raiders defense should be porous enough for the Browns running backs to find some holes.