Amari Cooper/Michael Crabtree at the Chicago Bears:

Cooper has been absolutely on fire these past two games and this could be the one that really makes him a household name. The Chicago secondary is abysmal and without Jared Allen or Jon Bostic this defense is lacking a punch. Cooper and Crabtree should abuse this secondary all day.

Jarvis Landry/Rishard Matthews at New York Jets:

The Jets are a good defense; let's get that out of the way now. Week 3 was a trap game but it was also a must win game for the Eagles. The Jets did not nearly have that level of motivation and it showed. This matchup has to do with whether or not Revis and Cromartie will suit up on Sunday. Even if Revis does Matthews should explode for a monster game thanks to Landry picking up the number 1 coverage.

Randall Cobb/James Jones/ Davante Adams at San Francisco 49ers:

Cobb and Rodgers might be the best quarterback/wide receiver tandem in the league. The 49ers do not have the defensive firepower to stop Aaron Rodgers and his collection of weapons. If Adams cannot play then Jones is a must start.

Keenan Allen/Stevie Johnson at Cleveland Browns:

This matchup has to do with the health of Joe Haden and how well the Browns did without him last week. Allen should be the primary receiver but in the event Haden is their Johnson should break out for another big game. The Browns defense has struggled against high powered offenses.

John Brown/Larry Fitzgerald at St. Louis Rams:

Brown and Fitzgerald can abuse these cornerbacks on the St. Louis Rams and with the way Carson Palmer is rolling I would not bet against whoever he throws too. Brown and Fitzgerald will be must starts against what is looking like a weak overall defense.