Latavius Murray at Chicago Bears: Murray is going to destroy the Bears for what could be his largest point total of the season. Even with a mediocre offensive line Murray should find a ton of running room against this porous defense.

Karlos Williams (at home) VS New York Giants: Williams should go off against the Giants defense especially without LeSean McCoy.  This places the lion's share of carries on Williams's shoulders and this game could get out of hand. The Giants should struggle against one of the best defenses in the league and that should provide ample opportunities for Williams to get a boatload of carries.

Joseph Randle at New Orleans Saints: Randle was an absolute monster in week 3 except he disappeared for the entire second half of the game. That turned out to be alright for fantasy owners as Randle had 3 touchdowns in the first half. Randle should not have a hard time finding the end zone against a horrific Saints defense. Randle is an RB1 for week 4.

Melvin Gordon (at home) VS Cleveland Browns:  Gordon should find a way to have a monster fantasy game against a Browns defense that is seemingly getting worse every week. The Browns will have a hard time corralling the speedy Gordon and he should be set to put up some solid points in a game that may get out of hand.