Buffalo Bills

LeSean McCoy (Running Back): McCoy looks like he is back to 100 percent and could potentially gash this Jaguars defense for his best game of the season. McCoy should break 100 yards in this game as the Jaguars defense has yet to stop anyone. The Bills should lean on their ground game as EJ Manuel will look to make another start without Percy Harvin or Sammy Watkins.

Charles Clay (Tight End): With Watkins and Harvin out Clay becomes the number 1 passing target and he should get the majority of red zone targets. Clay has been a dependable option of the last few weeks and should solidify his TE1 status against the Jaguars.

Jacksonville Jaguars

Allen Hurns/Allen Robinson (Wide Receivers): Both Hurns and Robinson have had amazing seasons so far. Robinson is a little banged up after suffering several contusions in week 6 which should leave the majority of the production to Hurns. Hurns may be a WR2 this week but he will have strong WR1 upside if Robinson's injury issues linger into the weekend.

Julius Thomas (Tight End): Thomas proved that he was worth every penny of his mega contract in his first game back. He saw the end zone and the most targets in the Jaguars offense. Thomas should continue to be a high level TE1 especially if Robinson struggles with his injury.

TJ Yeldon (Running Back): Yeldon has resumed practicing allowing the possibility for him to start in week 7. Yeldon should have a tough time against this Bills defense that remains stingy against the run even after losing some of their early season punch.