Indianapolis Colts
Andrew Luck (Quarterback): Bad matchup this week against Carolina and Luck has done nothing but struggle all year long. Luck has thrown 9 picks to 11 touchdowns this season.
TY Hilton/Donte Moncrief (Wide Receivers): Hilton is the clear cut number 1 wide receiver on the Colts which is why he will see a ton of top Carolina corner Josh Norman this week. Hilton should be limited thanks to Carolina's impressive coverage so Moncrief will have a chance to produce.
Frank Gore (Running Back): The Panthers actually give up the 5th most fantasy points to running backs in the league so Gore should be an excellent choice to start. It should be noted that Gore has not yet hit 100 yards on the season but this is most likely do to his terrible offensive line.
Carolina Panthers
Cam Newton (Quarterback): Newton does not throw for a lot of yards extends drives and scores touchdowns with his legs. I would be extremely surprised to see Newton have trouble with this defense.
Jonathan Stewart (Running Back): Indy has given up the 5th most fantasy points to running backs all season long so Stewart is a quality start this week. Plus the longer the Panthers offense keeps Andrew Luck off the field the better chance they have at winning.
Greg Olsen (Tight End): The Colts have allowed 1 touchdown to opposing tight ends all season long. If Olsen see's 10 to 15 targets I can see that changing however it is more likely the Panthers will lean on their ground attack. Olsen is still a low tier TE 1.