Both the St. Louis Rams (3-5) and San Francisco 49ers (6-2) will try to remain undefeated against divisional opponents when they'll clash with each other Sunday at 4:25 p.m. ET.

The Rams are looking for their first AFC West win this Sunday, as they are 0-3, but playing the division-leading 49ers will make getting that first division win difficult.

Quarterback Sam Bradford has completed 67 percent of his passes, averaging 258 yards per game, and has two touchdowns with two interceptions.

Bradford has thrown for 543 yards and two touchdowns with no interceptions in his only two starts against the 49ers. He hasn't lost to the 49ers as the starter, but this is the first time that San Francisco defensive coordinator Vic Fangio will get a chance to gameplan against him.

Meanwhile, the 49ers boasts the No. 2 defense in the NFL. They've allowed the second-lowest yards in the NFL (2,171), the fewest points in the NFL (103) and the fewest points per game (12.9).

Quarterback Alex Smith was nearly perfect his last time on the field, throwing 18 for 19 for 232 yards and three touchdowns en route to being named the NFC Offensive Player of the Week for the first time in his career.

Offensively, Michael Crabtree has stepped into his own, and has five touchdowns in his past four games against St. Louis. He's got 22 catches for 365 yards over his last four against them.

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