Houston Texans
DeAndre Hopkins (Wide Receiver): The Bills have given up the 13th most fantasy points to wide receivers this season however Hopkins did not have the production that we are accustomed too. This mostly had to do with game flow and a lack of competitiveness from the Saints. Hopkins should be ready to tear apart the Bills but if he doesn't look out fantasy owners.
Alfred Blue (Running Backs): The Bills give up the 12th most fantasy points to running backs this season and will likely be without Mario Williams for this contest. Blue is an early down back who has shown a lot of power on the goal line. If the Bills fail to contain the rush Blue could have a solid day.
Buffalo Bills
Sammy Watkins (Wide Receiver): Houston has given up the 8th fewest fantasy points and has only allowed 1 passing touchdown in the last 4 games. Watkins had a big week last week however he should return to low level production against this talented secondary.
LeSean McCoy (Running Backs): McCoy will be facing a defense that gives up the 11th most fantasy points to running backs however they are playing better than their rank implies. Luckily for McCoy that will not matter, the Bills are most effective when they're running the football so they will do anything to get McCoy going. With Karlos Williams looking like a scratch McCoy could be in for a big game.