Tottenham are in France to take on Ligue 1 outfit Lyon on Thursday at 1 p.m. ET.
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Tottenham are without their top scorer in the Europa League Jermain Defoe (ankle), while Younes Kaboul (knee) is still several weeks away from returning to first-team duty.
With Tom Huddlestone (knee) a doubt for the match and Brazilian enforcer Sandro (also knee) out for the remainder of the season, Scott Parker and Mousa Dembele are likely to continue in midfield.
Andre Villas-Boas may rotate his squad with one eye on Monday night's Premier League clash with West Ham, so Steven Caulker and Kyle Naughton could slot back into the defence.
Spurs' Portuguese boss has opted to rotate his goalkeepers in Europe, which means Brad Friedel is likely to start and thus deny ex-Lyon shot-stopper Hugo Lloris a reunion with his former club.
Meanwhile, Lyon have beaten Tottenham at home before, securing a 1-0 win over Bill Nicholson's Spurs in the 1967-68 European Cup Winners' Cup first leg - a replica of that scoreline on Thursday would send the French side through.
That 1-0 win over Tottenham was Les Gones' last home win over an English side, over 46 years ago. It is also their only home win over English teams, having drawn five and lost one of the other six encounters.
Lyon have won their last four European home games, recording victories in all three of their Europa League group games at the Stade de Gerland this year and beating APOEL in the last 16 of last season's Champions League.
Probable Lineups:
Lyon: Vercoutre, Reveillere, Bisevac, Lovren, Umtiti , Fofana, Gonalons , Lacazette, Grenier, Lopez, Gomis
Tottenham: Friedel, Walker, Gallas, Caulker, Naughton , Dembele, Parker, Lennon, Dempsey, Bale, Adebayor
