Real Madrid will face off against Malaga in their La Liga game Wednesday, knowing if they slip up, Barcelona could win the title at the weekend.
Barca are currently 11 points clear of Real Madrid with four games remaining. If Real lose or draw with Malaga, then Barcelona will be crowned La Liga champions with victory over Atletico Madrid at the weekend, irrespective of Real's result against Espanyol Saturday.
Mourinho, however, is not too concerned about that scenario, instead concentrating on the impeccable home record at the Bernabeu, where Real are still to lose a single game this season.
"None of the big European teams have ever done it," Mourinho said. "If they don't lose in the cup, they've lost a home game in the Champions or league. Every team has lost a home game and we've got two left to play in La Liga to finish the year undefeated.
"It's not an extremely important objective, but it's worth it to try to win these two home matches and finish the season undefeated because it would be good for the squad to start next season with this important capital in the Bernabeu."
Malaga have seen their bid for a top-four spot flounder in the last couple of games, but Mourinho is well aware of the threat posed by Manuel Pellegrini's men.
"Malaga are a dangerous team and if we don't play to the best of our ability we will have a hard time," he said. "They're a very good team and they play as a group.
"They're solid on defence, they have a great attack and they can create a lot of danger, especially on the counterattack. If we don't take it seriously this is a game we could lose."
Mourinho also named his back five for the game with Iker Casillas again missing out. "Diego Lopez, (Raul) Albiol, (Raphael) Varane, Nacho and (Fabio) Coentrao will play," Mourinho said. "To me Varane is the future of Real Madrid's central defence along with Ramos.
"Albiol deserves it and I've got confidence in him. Coentrao will play because I don't have another option and Diego Lopez as well because he's the best option that I think we have in the goal."
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Expected lineups: Real Madrid: Diego Lopez; Nacho, Varane, Albiol, Coentrao; Alonso, Modric; Di Maria, Ozil, Ronaldo; Benzema.
Malaga: Willy; Sanchez, Weligton, Demichelis, Antunes; Iturra, Camacho; Joaquin, Baptista, Isco; Santa Cruz.
Prediction: 4-2 to Real Madrid
