Week 4 kicks off with Thursday Night Football action as the San Francisco 49ers set for a road meeting against the hosting St. Louis Rams at 8:25 p.m. ET.
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The 49ers are looking to avoid their third consecutive loss against a Rams team that gave them plenty of complications back in 2012.
Since their 34-28 season opening win against the Green Bay Packers, the 49ers have looked nothing like the team they were expected to be as they chase for their second straight NFC title. In the last two games they've managed just 461 total yards, turned the ball over seven times and committed 18 penalties while being outscored 56-10 by the Seattle Seahawks and Indianapolis Colts.
San Francisco last dropped three in a row during the 0-5 start in 2010-the season prior to Jim Harbaugh's arrival to the team.
"We're not going to hang our heads," Harbaugh said. "Football is not easy, there are struggles.
"We've got some adversity, no question about it. We also have the rare opportunity to stare adversity in the face and whip it. That's our goal."
The 49ers will need to see increase production from quarterback sensation Colin Kaepernick who threw for 412 yards with three touchdowns and no interceptions in their season opener against the Packers, but 277 with no touchdowns and four interceptions the last two weeks.
