This Sunday five rookie quarterbacks will be making their NFL debuts. A few in particular have tough opponents to go up against in their debuts.
One quarterback is set to face the 2011's second-ranked defense while another is set to face last season's toughest pass rush.
That's tough, but that's football.
Here are a few rookie quarterbacks who face the toughest test in Week 1.
Brandon Weeden, Cleveland Browns vs. Philadelphia Eagles
Weeden will make his debut as a 28-year-old rookie and will be taking over an offense that has ranked among the NFL's worst for quite some time now.
Weeden will be starting his pro career against the Philadelphia Eagles' prolific pass rush, only adding more to the rookie's problems.
The Eagles notched 50 sacks in 2011 and added even more weapons to their defensive front when they selected cat-quick defensive tackle Fletcher Cox and rush end Vinny Curry in the draft. But before they can even think about containing that rookie duo, the Browns will have to find a way to stop veterans Trent Cole and Jason Babin getting to Weeden.
As if the pressure isn't enough, if Weeden does get the time to air it out, he will have to contend with press coverage from Nnamdi Asomugha and Dominique Rodgers-Cromartie.
Moving the ball will be Weeden's biggest challenge, as well as trying to keep pace with the dynamic Eagles offense led by Michael Vick, DeSean Jackson and LeSean McCoy.
Ryan Tannehill, Miami Dolphins vs. Houston Texans
Tannehill is preparing to face a fierce pass rush without proven, quality weapons in the passing game. Against the Houston Texans' blitz-happy 3-4, Tannehill could find himself in trouble early.
The Texans usually send five rushers after quarterbacks and even if Tannehill beats the pressure, he will be throwing into an opportunistic secondary.
Tannehill's best bet might be to try and fashion a big play early via the deep ball. That may encourage the Texans to temper the rush slightly.