Ajax will host Real Madrid as two of the most decorated clubs in European history will clash at Amsterdam Arena at 2:45 p.m. ET.
Ajax, who have four European cups to their name, lost their opening match of the campaign to Borussia Dortmund, but have had much success on their home field.
Ajax is on a 12-match winning streak at Amsterdam Arena in all competitions. The club's last home defeat came against Manchester United in the Europa League in February.
The Dutch's overall home record against Spanish opponents is eight wins, three draws and four loses, but has only one victory in its last seven games against Primera Division clubs.
Real Madrid, however, has beaten Ajax home and away in each of the last two season in the Champions League group stage.
Possible lineups:
Ajax: Vermeer; Van Rhijn, Alderweireld, Moisander, Blind; De Jong, Poulsen, Eriksen; Sana, Babel, Boerrigter
Real Madrid: Casillas; Ramos, Varane, Pepe, Marcelo; Alonso, Modric; Di Maria, Ozil, Ronaldo; Higuain
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