Philadelphia Eagles
Jordan Matthews (Wide Receiver) [Start]: Matthews is likely one of your best wide receivers so you should start him. He will not have a hard time against this Falcons secondary.
Nelson Agholor (Wide Receiver) [Sit]: Agholor is a rookie who is coming into his first game. Unless Bradford blows the doors off the Falcons then Agholor should be hard pressed to find targets.
DeMarco Murray (Running Back) [Start]: Murray would have been drafted high and is likely your second running back depending on when you took him so he is a must start. The Falcons defense has not handled the run well in the past and that should not change.
Sam Bradford (Quarterback) [Sit]: Bradford is a tempting option because he is truly unknown; no one knows how Chip Kelly's offense will look. That is why you should sit him this could literally be a massive bust. They are playing the Falcons defense but still Bradford is also still very injury prone so it would be wise to give your roster spot to someone who will be around all season long.
Darren Sproles (Running Back) [Sit]: Sproles will be handling the passing down work but could get moved to an even more reserve role based off of the way he handles the blitz. Sproles will get his plays that are made for him but that will be the only time he is on the field.
Atlanta Falcons
Matt Ryan (Quarterback) [Start]: We all know what we will get with Matt Ryan and even if he has a bad game he should hit around 18 fantasy points. We all saw the chemistry he had with Julio in the preseason linking up multiple times on single drives for touchdown passes. Now Ryan gets to play against what was one of the worst defensive backfields in the league. Ryan should do just fine against the Eagles defense.
Julio Jones (Wide Receiver) [Start]: Jones is a must start especially considering where you drafted him, come on don't get cute.
Roddy White (Wide Receiver) [Sit]: White is a sit because he will struggle to find any separation. White was a fantasy staple for the Falcons for many years however that just is not the case anymore. White at best is a streaming flex but even that may be too generous.
Tevin Coleman (Running Back) [Sit]: Coleman is a rookie who is running behind an awful offensive line. He also is second on the depth chart if Freeman can play.
Devonta Freeman (Running Back) [Sit]: Freeman has been sidelined with a hamstring injury so he should be worthy of a play when he is 100 percent healthy.