San Francisco 49ers
Carlos Hyde (Running Back): This game could go either way but the momentum favors the Gmen. Hyde should try to establish the run against a weak Giants defensive line and secondary. The lack of safety depth is a cause for alarm and this could give Hyde a lot of room to run. This is a trap game for the Giants.
Torrey Smith/Anquan Boldin (Wide Receivers): Smith and Boldin should have a good matchup this week if Kaepernick could ever get them the ball. Boldin will likely see the top coverage so things are shaping up for Smith to have a very productive day.
New York Giants
Odell Beckham JR/ Rueben Randle (Wide Receivers): ODB had a massive let down last week in the win against the Bills. The Bills ran press coverage and all of that physicality affected ODB negatively. He was even seen throwing punches at Bills players. ODB cannot make plays in physical coverage so expect a lot of that from the 49ers. Randle has shown his ability to make plays and should become a major factor in this game.
Eli Manning (Quarterback): Manning has had a solid fantasy year so far which is surprising considering the state of his offensive line. Manning should be tested against this 49ers pass rush and Eric Reid lurking in the secondary. Manning should be able to bring the Giants a W in this game however like I said earlier this could be a trap game.