Denver Broncos
Demaryius Thomas/Emmanuel Sanders (Wide Receivers): With Manning out maybe we can finally see what Thomas can do down the field. I know it is weird to want to be optimistic about Brock Osweiler but you should be especially if you own one of these players. It is a situation that simply cannot go wrong, no quarterback has played worse than Manning this year and it has hurt Thomas and Sanders fantasy value. Now they will look to make an impact against a defense that has struggled against the pass before. Manning's favorite target has been Sanders but it was clear after Manning was pulled out of the game that Brock Osweiler could lean on Demaryius a bit more than Sanders.
Ronnie Hillman/C.J. Anderson (Running Back): The Bears have given up the 13th fewest fantasy points to running backs and currently with both players trading weeks of production it seems as if this is a backfield to stay away from. Anderson did absolutely nothing last week so Hillman might have a lead on the starting job.
Chicago Bears
Alshon Jeffery (Wide Receiver): Jeffery needs to get healthy but he will be going up against Aqib Talib and this Denver secondary that has destroyed their opponents. Jeffery will likely be swallowed up in coverage but you have to start him even though he has a bad matchup.
Jeremy Langford (Running Back): He murdered the Rams so I would say there is a shot that he is just as productive and could end up being a matchup proof running back. Langford has had 2 huge games and his matchup with Denver should determine his floor for the year.
