Cleveland Browns at Seattle Seahawks: This one really needs no explanation, the Seahawks are red hot and the Browns are as cold as day old soup. Manziel is playing for his next NFL suitor and that mentality may bring out better play in the young quarterback but nothing could prepare him for a date with the Legion of Boom. They are playing like the Seahawks of old right now and unless the Browns pull off the biggest upset in NFL history, this one should be a blow out.
Tennessee Titans at New England Patriots: The Patriots have a great run defense and can make do in coverage. Belichick is the master of trick plays so I doubt Mariota will be catching a ton of touchdowns in this contest. When you look at the Titans ground game it should be assumed that none of these running backs will be able to produce any more effectively than they have all season long. The Patriots could seriously run up the score in this contest.
Kansas City Chiefs at Baltimore Ravens: The Ravens are in desperate trouble and are currently staring at a high draft pick which is a plus. The Chiefs are rolling and they should take care of business on the road. With Joe Flacco, Steve Smith, and Justin Forsett, all out for the season this might be one of the safest defensive fantasy matchups of the week.
Arizona Cardinals at Philadelphia Eagles: This one would be a surprise if the Eagles managed to turn this into a game. The Eagles have struggled plenty but have managed to stay tied in the NFC East (which means they haven't lost). That ends in week 15, the Eagles do not have the personnel or depth to take on the Cardinals who are very deep on both sides of the ball. The Cardinals should generate a ton of turnovers in week 15.