Two teams that have already qualified to the next round - Rubin Kazan and Inter Milan -- will face off with top spot up for grabs in the Europa League.
Inter and Rubin have sealed their progress and are joint top on ten points. The Italian side's manager Andrea Stramaccioni, who has left some of his big names at home, expects a tough fight against their Russian opponents.
"Since the draw was made we knew that we'd have three long away trips," he said. "We've done two and tomorrow we're up against Rubin, who are top-class opposition, the best in the group along with us.
"It's important for us to focus on tomorrow's game. Inter have an injury crisis at the moment and we've played lots of games without three experienced center-backs and lots of games without five midfielders.
"But we've still managed to keep playing our usual way and not lose our identity. This match against Rubin is also an important moment for our youth academy, where I come from myself, because it's an opportunity to see if some of these youngsters might be ready if they're called upon.
"If in the early stage of the Europa League we made changes through choice, now we're doing it out of necessity. We'll give it a go tomorrow, but once we get to the knockout phase it will definitely be more difficult to change so many players because the team as a unit will be important."
Stramaccioni also paid tribute to Rubin manager Kurban Berdyev. "I have great respect for Rubin's coach, he's one of the best in Europe. People don't talk about him much but I've seen lots of his games and he'll make it hard for us as he did in Milan. It will be a great match to watch."
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