With Arsenal in "crisis" mode, the Gunners travel to Greece to face an Olympiakos side who have nothing but pride to play for in the Champions League.
Arsenal and Schalke have already qualified from Group B, with only top spot still up for grabs. If the Gunners get all three points against the Greek side and Schalke drop points against Montpellier in France, Arsenal will go through as group winners.
However, the English Premier League side will have to make do without several of their first team players, with the likes of Jack Wilshere, Theo Walcott, Santi Cazorla, Olivier Giroud, Lukas Podolski and Mikel Arteta left behind in London.
"This game comes at a good time," Arsene Wenger told reporters. "We have less pressure, as we are already through to the last 16 and we want to finish well and top of our group. It also gives us the opportunity to see players who have had less time on the pitch.
"The only pressure I feel right now is the one I always feel: to win the next game, for the team to play the football I love. The rest doesn't affect me at all.
"I will tell my players not to be surprised by the commitment of Olympiakos. They are a historic club with huge pride. The match against us is their opportunity to show their quality. They have had a good campaign and I believe they were unlucky against us in London and against Schalke a fortnight ago. They came close to qualifying."
Arsenal are going through one of their bad patches, with their 2-0 loss to Swansea on Saturday consigning them to tenth place in the Premier League, their worst ever start under Arsene Wenger.
However, the Gunners will be happy to play a game that does not hold too much importance, although a win will go a long way in restoring some of the confidence that has been sorely lacking over the past few months.
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Expected lineups: Olympiakos: Carroll; Torossidis, Manolas, Siovas, Holebas; Greco, Modesto, Ibagaza; Vlachodimos, Djebbour, Abdoun.
Arsenal: Szczesny; Jenkinson, Vermaelen, Squillaci, Meade; Coquelin, Ramsey, Rosicky; Arshavin, Oxlade-Chamberlain, Gervinho.
Prediction: 2-1 to Arsenal
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