The top-ranked New England Patriot offense will take on the top-ranked San Francisco 49ers defense for Sunday night football matchup at 8:20 pm ET.
New England (10-3), which will try for its 14th straight win in December and 21st straight at home during the month, has already won the AFC East title and trails Houston by one game for the conference's top seed.
Tom Brady has thrown for 29 touchdowns and just four interceptions this season, including 19 with only one pick during the team's seven-game winning streak.
Brady will try to make the most of a banged-up receiving corps after Donte' Stallworth (ankle) and Julian Edelman (foot) were placed on injured reserve this week.
As a result, the team re-signed Deion Branch for the second time this season.
With tight end Rob Gronkowski also out with a broken forearm, Aaron Hernandez stepped up nicely with eight catches for 58 yards and two scores against Houston.
Stevan Ridley will try to continue to give the Patriots a solid option in the running game after scoring a touchdown in six consecutive contests.
Meanwhile, the 49ers lead the NFL in scoring defense (14.2 points per game), but the Patriots have the NFL's highest-scoring offense (36.3) and have put up 42 or more points in four of their past six games.
Colin Kaepernick was 18 of 23 for 185 yards in a 27-13 win over Miami on Sunday. He's completed 67.4 percent of his passes as a starter and averaged 8.3 yards per attempt.
Kaepernick showed off his running ability with a late 50-yard touchdown to seal the victory over the Dolphins. He's already third among NFL quarterbacks with 351 yards on the ground -- 7.6 per carry -- and five rushing touchdowns.
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