Lazio will look to enter the quarterfinals of the Coppa Italia with a victory over Siena in their pre-quarterfinal matchup.
The Rome club will be the overwhelming favorites to join the likes of AC Milan, Inter Milan, Roma and Juventus in the next round, with Siena currently the bottom club in Serie A.
Siena are 20th, after having picked up a mere 11 points from 17 points, while Lazio are a lofty third in the Italian league table.
Siena's poor form in the Serie A led to the club firing their manager Sersi Cosmi, with Beppe Iachini given the task of turning the team's fortunes around.
Lazio manager Vladimir Petkovic criticized Siena's decision to let go of Cosmi. "Unfortunately we will play them with a new coach," Petkovic told reporters during his pre-match press conference. "It is not a good thing for football to see these things happening at a club.
"We do not know what sort of opponent we will face but we are used to focusing on ourselves, so it won't be too much of a problem."
Petkovic also revealed some unrest going on within his own camp, with Mauro Zarate excusing himself from training with the first team and making himself unavailable for the match against Siena.
"He's put himself out of things," Petkovic added. "He won't be called up for tomorrow's (Wednesday's) encounter.
"He's asked to be placed to one side and is currently training on his own. We'll see what happens next."
Zarate has hardly been used by Petkovic this season, with the Argentine forward making just a solitary appearance in the Serie A so far.
Meanwhile, Siena's new boss Iachini said his side were capable of pulling off an upset against Lazio and also pulling themselves away from the relegation zone.
"This opportunity arrived, the club showed great admiration for the work I've done and I am happy," Iachini told Sky Sport Italia.
"It's a shame for Cosmi, who is a friend, but football is like that for us. We are starting from a difficult position in the table, but we are here to work and put all our efforts on to the field.
"In tactical terms we will try to bring some of our ideas. The situation is not easy, but with enthusiasm and hard work we can emerge from it.
"This side has the potential to achieve safety, score more goals and make fewer mistakes."
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Prediction: 3-0 to Lazio
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