Barcelona travel to relegation-threatened Celta Vigo, looking to increase their already bulging 13-point lead at the top of La Liga.
Barca are well on their way to another Spanish league title with a double-digit lead over Real Madrid already established with a mere ten games remaining in the rest of the season.
The Spanish side were irresistible in their 4-0 win over AC Milan and will have one eye on the midweek Champions League game against Paris Saint Germain.
However, Barca received a huge boost with Tito Vilanova returning to the club following treatment in New York for cancer. The Barcelona manager took a training session ahead of the Celta game, but will not travel to Vigo to take his place in the dugout.
"He and the doctors agreed that it would be good to do this," Barca assistant coach Jordi Roura said. "He's just finished the treatment and the 7 or 10 days after completing the treatment are very hard.
"We preferred to wait, although he's come to training. Depending on his progress there's a good chance he'll travel to Paris (for the Champions League quarterfinal).
"Tito's return means a lot. The boss is back and that's always important. It's an injection of joy and vitality. It's a very important boost for the squad."
Barca will not have it easy against Celta, who will be desperate to pick up points. They currently lie second bottom on 23 points, and are three points adrift of safety.
"Celta are playing for their survival and for them it is a matter of life or death, which makes it difficult," Roura added. "We will go into the game with the maximum intensity and seriousness. It is another step forward in achieving the final objective."
Barca will be hampered by quite a few absentees with Xavi Hernandez, Carles Puyol, Pedro Rodriguez, Adriano and Jordi Alba all out inured, while goalkeeper Victor Valdes is suspended.
Celta have plenty of problems of their own, with Michael Krohn-Dehli, Iago Aspas, Sergio Alvarez, Hugo Mallo, Samuel Llorca, Alex Lopez and Andres Tunez all missing.
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Expected lineups: Celta Vigo: Varas; Johny, Cabral, Demidov, Lago; Oubina, Insa; Fernandez, Bermejo, Lucas; Park.
Barcelona: Pinto; Alves, Pique, Mascherano, Montoya; Thiago, Busquets, Fabregas; Villa, Messi, Sanchez.
Prediction: 4-0 to Barcelona