1.How will Rex Ryan's rushing game look?

LeSean McCoy is expected to play a huge role in Rex Ryan's rushing game. With Fred Jackson sidelined can Karlos Williams, Anthony Dixon, or Bryce Brown make a definitive impact? The Bills will run the ball a lot which will require a lot of healthy running backs. Karlos Williams is already ahead of Dixon and Brown for third string duties so what kind of impact can he make in preseason?

2. Can Cam Newton reach the next level?

Cam Newton now has the weapons to take this team far into the playoffs. They won the NFC south last year with a losing record so can Newton lead Carolina to more wins in 2015?

3. How will Devin Funchess play?

Funchess is a big target with a lot of athletic ability. Newton must take advantage of the mismatches he creates. Funchess needs to come out aggressive and create space for himself to make plays. Funchess and Benjamin will be an interesting duo to watch this season.

4. Is this Bill's defense ready to dominate?

The Bill's defense is going to incredibly important this season because of the lack of offensive explosiveness. The Bills are going to need to score off turnovers and put their offense in a good position to succeed.

5. How will the Bill's quarterbacks perform?

Can Matt Cassel, Tyrod Taylor, or EJ Manuel separate themselves from the pack? Cassel is getting the start because of his veteran status but each quarterback should be getting plenty of reps. EJ Manuel remains at the bottom of the depth chart but some strong preseason play can bring him back into the fold.