Eli Manning and this New York Giants offense will have a lot of work ahead of them this week as the will face a Bills defense that has been absolutely dominant in the early part of the 2015 NFL season.

Manning will struggle to have a clean pocket as the Bills will certainly bring a ton of pressure against the Giants makeshift offensive line. The Giants will need to play their best football of the season (so far) to beat these Bills as they look in top form however they will be without star running back LeSean McCoy. Karlos Williams will be his replacement and he should test this banged up Giants defense.

Key Factors:

Can Tyrod Taylor take advantage of a weak Giants secondary?

Tyrod Taylor should have a field day against a Giants secondary that is missing most of their starting personal. Taylor also should be able to utilize his legs and gain some yards on the ground against these backup Giants safeties. Taylor could be in for a huge day.

Can Karlos Williams make the most of his starting role with LeSean McCoy out?

Williams will need to make the most out of this starting opportunity because the Bills are going to need him to make plays in order for Buffalo to control the clock. It will be interesting to see now that Williams is their every down back if he will be replaced for goal line situations by Anthony Dixon. Dixon is the third string running back in this offense but has the size and power to get into the end zone.