Defending champions Atletico Madrid and Liverpool suffered defeats on Matchday 4 of the Europa League, as Edinson Cavani scored four goals to help Napoli beat Dnipro.
Newcastle United came from two goals down to hold Club Brugge 2-2, while Tottenham got their first win of the campaign with a 3-1 result over NK Maribor, thanks to a hat-trick from Jermain Defoe.
In Portugal, Atletico crashed to their second straight defeat, after their 2-0 loss to Valencia in the La Liga at the weekend, to Academica, a club that is currently lying tenth in the Portuguese league table. Wilson Eduardo was the hero, scoring both the goals in the 2-0 win.
Atletico still sit top of Group B, but the loss allowed Viktoria Plzen to join them at the top thanks to a 4-0 win over Hapoel Tel Aviv.
The outstanding individual performance of the night though, will not got to Eduardo, as Cavani netted all four goals, with Napoli coming from 2-1 down to post a 4-2 win over Group F leaders Dnipro.
In Russia, a goal from Lacina Trarore in first half stoppage time was enough to give Anzhi Makhachkala a 1-0 victory over a youthful, but ineffective Liverpool side.
Vurnon Anita and Shola Ameobi scored two goals in the space of two minutes late in the first half to earn their side a 2-2 draw, after Ivan Trickovski and Jesper Jorgensen had given the home side Brugge a 2-0 lead inside the first 20 minutes.
Newcastle manager Alan Pardew reserved special praise for the Ameobi brothers - Shola and Sammy - after the duo impressed. "I thought they were both good tonight," Pardew said. "We had Ameobi to Ameobi -- which is almost like a song -- for the second goal, which was nice.
"It was a great little turn from Sammy. He has just got this way of getting out of corners that I have not seen many players being able to get out of. He wriggles out of situations.
"He still needs to tighten up a little bit on the tactical and intelligence sides of the game. He takes people on where perhaps he should pass.
"But he will learn that. He showed his talent tonight - and he marks at set-plays, which he needs to do. He's 6'5".
"He's not very good at it, but he's learning."
Results: Anzhi 1-0 Liverpool; Neftci 0-1 Rubin; Academica 2-0 Atletico; Udinese 2-3 Young Boys; Plzen 4-0 H. Tel-Aviv; Marseille 2-2 Monchengladbach; Club Brugge 2-2 Newcastle; Bordeaux 1-0 Marítimo; Molde 1-2 Steaua; Kobenhavn 0-2 Stuttgart; AIK 1-0 PSV; Napoli 4-2 Dnipro; Fenerbahce 2-0 AEL; Sporting 1-1 Genk; Tottenham 3-1 Maribor; Basel 1-0 Videoton; Partizan 1-3 Internazionale; Athletic 2-3 Lyon; Lazio 3-0 Panathinaikos; Leverkusen 3-0 Rapid Wien; Hannover 3-2 Helsingborg; Twente 0-0 Levante; H. Kiryat Shmona 1-1 Sparta Praha; Metalist 3-1 Rosenborg.