Two teams struggling for goals and confidence meet at the Britannia Stadium, with Queens Park Rangers looking for their first win of the new English Premier League season, as Stoke go in hunt for just their second.
Six draws from ten matches have meant Stoke sit in 15th place, with just nine points, while QPR are worse off on four points from their ten games.
Stoke have only scored eight goals all season, the same number as QPR, and the Potters manager has asked his players to "be ruthless" in front of goal.
"We have got to become more ruthless in the final third of the pitch," Pulis told reporters at his pre-match press conference. "We've had a good look at the statistics and they support the fact that our performances have been good in a lot of respects, apart from in the final third.
"If we're going to win matches, then we've got to improve in that area because we should have scored more goals in our Premier League matches so far.
"We've looked solid at the back, we've looked good going forward and we've created chances. But as we saw at Norwich, we're not making the most of them."
Pulis believes their position in the Premier League table, does not tell the whole story of their season so far. "We've talked a lot about the fact that we've had a particularly tough start to the season, but there are no easy matches at this level," he said. "Six of our first ten games have been away from home and, overall, I think we have played much better than we have done in the previous four seasons.
"We are unbeaten at home so far and we have played Manchester City and Arsenal in that time, so there is good reason for us to be positive in our outlook.
"It's important people stay nice and calm. As I've said many times before, you have to be level headed at all times. That means you don't get too carried away when things are going well, just as you don't get too downhearted when they're not so good."
Rory Delap is ruled out with the midfielder set to undergo a hernia operation next week, while Michael Owen will also miss the QPR game with a hamstring injury.
For QPR, Stephane M'Bia will serve the second of his three-match suspension, while Fabio is also ruled out. Captain Park Ji-Sung is a major doubt for Saturday's game.
To watch Stoke City vs QPR Live Stream, click here.
Expected lineups: Stoke: Begovic; Cameron, Huth, Shawcross, Wilkinson; Adam, NZonzi, Whitehead, Kightly, Walters; Crouch.
QPR: Cesar; Bosingwa, Ferdinand, Nelsen, Traore; Granero, Diakite; Mackie, Taarabt, Hoiltett; Cisse.
Prediction: 1-0 to QPR
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