Denver Broncos
Demaryius Thomas/Emmanuel Sanders (Wide Receivers): Sanders and Osweiler cannot find the chemistry that most Denver fans were hoping for. On the other hand this has made Thomas's targets multiply. This defense allows 279 passing yards on average and Thomas is the only person in this offense getting double digit targets. Thomas should be the leading man for this matchup.
Ronnie Hillman (Running Backs): Hillman is facing a defense that has allowed the 3rd fewest fantasy points to running backs all season long. The Steelers have been extremely disciplined when it comes to the ground game and with C.J. Anderson practicing again it is likely his production will be limited. Hillman did not do much with the start he got last week.
Pittsburgh Steelers
Antonio Brown/Martavis Bryant (Wide Receivers): This will be one for the ages the best secondary versus arguably the best wide receiving tandem in the NFL. I cannot predict how this one will go down but the Broncos will clearly have the edge in this matchup. Bryant has only averaged 55.7 yards in games where he has faced an elite secondary.
Ben Roethlisberger (Quarterback): Roethlisberger plays better when he is playing a tough secondary, on average he has 300 plus passing yards going up against elite pass defenses. Big Ben has suffered 3 interceptions of the span of three games. This defense has only allowed 13 passing touchdowns so it is likely Big Ben will struggle this week.
DeAngelo Williams (Running Back): This defense allows the 11th fewest fantasy points to running backs averaging around 84.3 rushing yards per game. The Broncos have allowed 8 rushing touchdowns so he could see some action on the goal line. Williams is only a flex start against this defense.