San Francisco 49ers

Shaun Draughn (Running Back): Over the last few games Detroit has gotten pretty stiff against the run. With Draughn not practicing earlier in the week he will be a risky fantasy play heading into week 16. Draughn has not gotten into the end zone in 2 weeks which gives little hope for his red zone chances in this matchup.

Detroit Lions

Calvin Johnson/Golden Tate (Wide Receiver): With Calvin Johnson limited for the last 2 weeks he has been a fantasy bust for the last two weeks. Johnson has only 1 reception in his last two games making him almost a non-factor in the last two games. If Johnson cannot play to his fullest abilities Tate should see the extra work. Tate got all the goal line targets last week so he could be in for another big game.

Ameer Abdullah (Running Back): San Francisco has given up a ton of fantasy points to running backs this season. With Abdullah's resurgence in week 15 he has finally become a legitimate option for flex positions. The Lions are now relying mainly on Abdullah for his big play capabilities, with the 49ers giving up on average 128.6 yards per carry Abdullah could be in for another big game. If he gets the goal line work the 49ers also give up the most rushing touchdowns in the NFL.